Dramamine, just like Benadryl, is fairly safe for dogs when properly dosed
Here are a few different things you can do to help minimize your dog’s car sickness while traveling
The typical dose is 1 mg/lb, and should be administered about 30 minutes before your planned journey so the effects have time to kick in
A small dog will need much less than a big dog to receive the same positive effects
Dramamine is an antihistamine that helps limit symptoms of motion sickness
If you have large dogs that weigh 100 pounds or more, check with your veterinarian about a proper dose first
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Drowsiness, constipation, blurred vision, or dry mouth /nose/throat may occur
Itching
It takes effect quickly, typically within 1–2 hours of administration
Many human OTC products combine Benadryl with decongestants like pseudoephedrine or phenylephrine
Dwight Andrew Alleyne warns that
Many adult dogs become anxious or even nauseous during After the first Dramamine administration, you can talk to your vet about your dog’s reaction
Official answer
Note that this dog is properly secured in the vehicle with a padded car-safety harness that hooks to the seatbelt apparatus and has a dog hammock